• LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro 

      Halvorsen, Bente; Santilli, Francesca; Scholz, Hanne; Sahraoui, Afaf; Gulseth, Hanne Løvdal; Wium, Cecilie; Lattanzio, Stefano; Formoso, Gloria; Di Fulvio, Patrizia; Otterdal, Kari; Retterstøl, Kjetil; Holven, Kirsten Bjørklund; Gregersen, Ida; Stavik, Benedicte; Bjerkeli, Vigdis; Michelsen, Annika; Ueland, Thor; Liani, Rossella; Davi, Giovanni; Aukrust, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-15)
      Aims/hypothesis: Activation of inflammatory pathways is involved in the pathogenesis of type 2 diabetes mellitus. On the basis of its role in vascular inflammation and in metabolic disorders, we hypothesised that the TNF superfamily (TNFSF) member 14 (LIGHT/TNFSF14) could be involved in the pathogenesis of type 2 diabetes mellitus. <p>Methods: Plasma levels of LIGHT were measured in two cohorts of ...
    • SARS-CoV-2 vaccines are not associated with hypercoagulability in apparently healthy people 

      Garabet, Lamya Samir Noori; Eriksson, Anna Maria; Tjønnfjord, Eirik; Cui, Xueyan; Olsen, Magnus Kringstad; Jacobsen, Hege; Jørgensen, Camilla Tøvik; Mathisen, Åse-Berit; Mowinckel, Marie-Christine; Ahlen, Maria Therese; Sørvoll, Ingvild Hausberg; Horvei, Kjersti Daae; Ernstsen, Siw Leiknes; Lægreid, Ingvild Jenssen; Stavik, Benedicte; Holst, Rene; Sandset, Per Morten; Ghanima, Waleed (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)
      Background: SARS-CoV-2 adenoviral vector DNA vaccines have been linked to the rare but serious thrombotic postvaccine complication vaccine-induced immune thrombotic thrombocytopenia. This has raised concerns regarding the possibility of increased thrombotic risk after any SARS-CoV-2 vaccines. <p><p>Objectives: To investigate whether SARS-CoV-2 vaccines cause coagulation activation leading to a ...